Background & objectives: Women with a high quality of life are the bases of healthy families and happiness. Quality of life is related with different aspects of health, physical safety, mental and social life of the people and influenced by many factors. The purpose of this study was to predict the quality of life of married women based on sexual attitude and knowledge and personality traits.

Methods: The design of this study was correlational and statistical population comprised of all married women in Rasht, Iran. From this population, 150 married women were selected using convenience sampling method. The used tools were Quality of life Questionnaire of World Health Organization, Marital Sexual Function Scale and Five-Factor Personality Questionnaire. Data analysis was performed through Pearson&rsquos correlation coefficient and regression analysis.

Results: The findings showed a positive significant correlation between sexual attitude and knowledge with quality of life of married women and there was positive correlation between personality dimensions of extraversion, openness, conscience and pleasant with quality of life. Also there was negative correlation between personality dimensions of neuroticism with quality of life. The results of regression analysis also revealed that 45% of the total variance of quality of life can be explained by sexual knowledge, attitude and personality traits.

Conclusion: Hence, it can be concluded that with increasing the level of knowledge and sexual attitude of married women, the quality of life increases. On the other hand, having the features such as extraversion, flexibility, agreeableness and accountability can increase women&rsquos quality of life and in contrast, the characteristic of neuroticism decreases the quality of life among married women. Therefore, considering the importance of quality of life of married women and role of knowledge and sexual attitude and personality traits to predict it, attention to women's awareness about sexual knowledge and attitude and breeding desirable personality traits would be necessary.