Abstract

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Background & objectives:�Urinary tract infections account for about 40% of hospital acquired (nasocomial) infections, and about 80% of them are associated with urinary catheters. This study was conducted to determine the prophylactic effect of one-dose Amikacin on acquired infection related to catheterization.

Methods:�A double blind, clinical-controlled trial of prophylactic one dose (500 mg) Amikacin IV was performed on selected groups of 60 patients of Fatemi Hospital in Ardabil, who had bladder catheter. Patients were randomly assigned to receive Amikacin and placebo (n=30 cases in each group) and were adjusted for age as much as possible. Before and after intervention the urine sample was taken from all patients and to determine the type of microorganisms the simple and selective culture media (such as nutrient agar, EMB agar) and differential tests for the detection of specific isolated microorganisms (Coagulase test Garv Manitol IMVIC were performed. The data analyzed using descriptive-analytical statistics by SPSS statistical software v.16.

Results: The findings showed that the mean urinary catheter days in the intervention group were 7.06 and in control group was 7.5 days. The prevalence of bacteriuria was 6.6% in the intervention group and 26.6% in the control group [RR: 4.03] (p≤0.04).  The most common microorganisms isolated were E. coli 13.3 3% and Klebsiella 13.33%.

Conclusion: There was some evidence that one dose of Amikacin prophylaxis can reduce the rate of bacteriuria.

Keywords:�Amikacin, Prophylaxis, Catheter Related Urinary Infection.