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Volume 27, Issue 1 (spring 2025)                   JHC 2025, 27(1): 66-80 | Back to browse issues page

Ethics code: IR.UMA.REC.1403.016
Clinical trials code: IRCT20240521061854N1


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Alaei Kalajahi M, Atadokht A, Porzoor P. Effectiveness of Computer-based Cognitive Rehabilitation on Positive and Negative Symptoms and Cognitive Flexibility in Patients with Schizophrenia. JHC 2025; 27 (1) :66-80
URL: http://hcjournal.arums.ac.ir/article-1-1607-en.html
Department of Psychology, University of Mohaghegh Ardabili, Ardabil, Iran
Abstract:   (120 Views)
Background: Schizophrenia is a complex mental health disorder characterized by a combination of positive and negative symptoms, as well as cognitive impairments such as deficits in cognitive flexibility. These factors significantly impact the quality of life and functional outcomes of patients. This study aimed to evaluate the effectiveness of computer-based cognitive rehabilitation on positive and negative symptoms and cognitive flexibility in patients with schizophrenia.
Methods: This was a semi-experimental study with a pre-test, post-test, and follow-up design with a control group. The study population included all patients diagnosed with schizophrenia who were hospitalized in psychiatric treatment and rehabilitation centers in Ardabil city. A total of 30 patients diagnosed with schizophrenia based on psychiatric evaluations and clinical interviews were selected using purposive sampling and randomly assigned to experimental and control groups. Data collection tools included the Positive and Negative Syndrome Scale (PANSS) for schizophrenia and the computerized version of the simple Stroop test. The experimental group underwent computer-based cognitive rehabilitation using Captain's Log software over 12 sessions, each lasting 45 minutes, while the control group received no intervention. Data was analyzed using repeated measures ANOVA using SPSS v26.
Results: The results indicated that computer-based cognitive rehabilitation significantly reduced positive and negative symptoms of schizophrenia and improved cognitive flexibility in patients (p < 0.05). Furthermore, Bonferroni post-hoc tests revealed that changes observed in positive and negative symptoms and cognitive flexibility during the post-test phase were maintained during the follow-up phase.
Conclusion: Considering the effectiveness of computer-based cognitive rehabilitation in addressing positive and negative symptoms as well as cognitive flexibility in patients with schizophrenia, this intervention can play a vital role in comprehensive therapeutic strategies. Ultimately, it can contribute to improving clinical symptoms and functional abilities in individuals with schizophrenia.

 
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Type of Study: Applicable | Subject: Psychiatric Nursing
Received: 2024/12/10 | Accepted: 2025/05/20 | Published: 2025/03/30

References
1. Vos T, Lim SS, Abbafati C, Abbas KM, Abbasi M, Abbasifard M, et al. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. The Lancet. 2020;396(10258):1204-22. [DOI:10.1016/S0140-6736(20)30925-9] [PMID]
2. Association AP. Diagnostic and statistical manual of mental disorders. 5th ed. DSM-5-TR ed. Washington, DC: American Psychiatric Publishing; 2022.
3. Swora E, Boberska M, Kulis E, Knoll N, Keller J, Luszczynska A. Physical activity, positive and negative symptoms of psychosis, and general psychopathology among people with psychotic disorders: a meta-analysis. Journal of Clinical Medicine. 2022;11(10):2719. [DOI:10.3390/jcm11102719] [PMID] []
4. Khakbaz H, Khanjani MS, Younesi SJ, Khodaie Ardakani MR, Safi MH, Hosseinzadeh S. Effectiveness of cognitive-behavioral therapy on the positive and negative psychotic symptoms and emotion regulation of patients with schizophrenia spectrum disorders. Archives of Rehabilitation. 2023;24(1):2-27. [DOI:10.32598/RJ.24.1.1450.3]
5. Kaar SJ, Natesan S, Mccutcheon R, Howes OD. Antipsychotics: mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology. Neuropharmacology. 2020;172:107704. [DOI:10.1016/j.neuropharm.2019.107704] [PMID]
6. Oh SL, Vicnesh J, Ciaccio EJ, Yuvaraj R, Acharya UR. Deep convolutional neural network model for automated diagnosis of schizophrenia using EEG signals. Applied Sciences. 2019;9(14):2870. [DOI:10.3390/app9142870]
7. Cella M, Roberts S, Pillny M, Riehle M, O'donoghue B, Lyne J, et al. Psychosocial and behavioural interventions for the negative symptoms of schizophrenia: a systematic review of efficacy meta-analyses. The British Journal of Psychiatry. 2023;223(1):321-31. [DOI:10.1192/bjp.2023.21] [PMID] []
8. Dienel SJ, Lewis DA. Alterations in cortical interneurons and cognitive function in schizophrenia. Neurobiology of Disease. 2019;131:104208. [DOI:10.1016/j.nbd.2018.06.020] [PMID] []
9. McCutcheon RA, Keefe RS, McGuire PK. Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment. Molecular Psychiatry. 2023;28(5):1902-18. https://doi.org/10.1038/s41380-023-01984-6 [DOI:10.1038/s41380-023-01949-9] [PMID] []
10. Mihaljević-Peleš A, Bajs Janović M, Šagud M, Živković M, Janović Š, Jevtović S. Cognitive deficit in schizophrenia: an overview. Psychiatria Danubina. 2019;31(suppl 2):139-42.
11. Klaus F, Mitchell K, Liou SC, Eyler LT, Nguyen TT. Chemokine MCP1 is associated with cognitive flexibility in schizophrenia: a preliminary analysis. Journal of Psychiatric Research. 2021;138:139-45. [DOI:10.1016/j.jpsychires.2021.04.007] [PMID] []
12. Liu T, Hu L, Lv Y, Jin Y. Does perceived coolness promote tourists' participation in sports tourism? Social Behavior and Personality. 2024;52(1):1-12. [DOI:10.2224/sbp.]
13. Miles S, Howlett CA, Berryman C, Nedeljkovic M, Moseley GL, Phillipou A. Considerations for using the Wisconsin Card Sorting Test to assess cognitive flexibility. Behavior Research Methods. 2021;53(5):2083-91. [DOI:10.3758/s13428-021-01551-3] [PMID]
14. Huang J, Siu CT-S, Cheung H. Longitudinal relations among teacher-student closeness, cognitive flexibility, intrinsic reading motivation, and reading achievement. Early Childhood Research Quarterly. 2022;61:179-89. [DOI:10.1016/j.ecresq.2022.07.009]
15. Cartwright KB, Marshall TR, Huemer CM, Payne JB. Executive function in the classroom: cognitive flexibility supports reading fluency for typical readers and teacher-identified low-achieving readers. Research in Developmental Disabilities. 2019;88:42-52. [DOI:10.1016/j.ridd.2019.01.011] [PMID]
16. Park Y, Ammerman BA. For better or worse?: the role of cognitive flexibility in the association between nonsuicidal self-injury and suicide attempt. Journal of Psychiatric Research. 2023;158:157-64. [DOI:10.1016/j.jpsychires.2022.12.040] [PMID]
17. Najafi Gharehasani E, Yazdanbakhsh K, Moment K. Predicting vicarious post traumatic growth based on cognitive flexibility and cognitive reappraisal in nurses providing services to Kermanshah earthquake victims. Journal of Health and Care. 2020;22(1):17-24. [Persian] [DOI:10.29252/jhc.22.1.17]
18. Kalia V, Knauft K. Emotion regulation strategies modulate the effect of adverse childhood experiences on perceived chronic stress with implications for cognitive flexibility. PloS One. 2020;15(6):e0235412. [DOI:10.1371/journal.pone.0235412] [PMID] []
19. Atadokht A, Mohamadi G, Mohamadi I. The effectiveness of aerobic exercise training of positive and negative symptom of patients with schizopheernia. Journal of Health and Care. 2017;2(19):107-16. [Persian]
20. Matsuda Y, Makinodan M, Morimoto T, Kishimoto T. Neural changes following cognitive remediation therapy for schizophrenia. Psychiatry and Clinical Neurosciences. 2019;73(11):676-84. [DOI:10.1111/pcn.12912] [PMID]
21. Harvey PD, Bowie CR. Cognitive enhancement in schizophrenia: pharmacological and cognitive remediation approaches. Psychiatric Clinics of North America. 2012;35(3):683-98. [DOI:10.1016/j.psc.2012.06.008] [PMID] []
22. Zoupa E, Bogiatzidou O, Siokas V, Liampas I, Tzeferakos G, Mavreas V, et al. Cognitive rehabilitation in schizophrenia-associated cognitive impairment: a review. Neurology International. 2022;15(1):12-23. [DOI:10.3390/neurolint15010002] [PMID] []
23. Best MW, Milanovic M, Tran T, Leung P, Jackowich R, Gauvin S, et al. Motivation and engagement during cognitive training for schizophrenia spectrum disorders. Schizophrenia Research: Cognition. 2020;19:100151. [DOI:10.1016/j.scog.2019.100151] [PMID] []
24. Wykes T, Stringer D, Boadu J, Tinch-Taylor R, Csipke E, Cella M, et al. Cognitive remediation works but how should we provide it? an adaptive randomized controlled trial of delivery methods using a patient nominated recovery outcome in first-episode participants. Schizophrenia Bulletin. 2023;49(3):614-25. [DOI:10.1093/schbul/sbac214] [PMID] []
25. Tayeby F, Hamid N, Omidian M. Effectiveness of Captain Log cognitive rehabilitation software on auditory and spatial working memory among people with depressive symptoms. Journal of Cognitive Psychology. 2021;9(1):84-101. [Persian]
26. Jaiswal S, Saxena P, Chowdhury D, Abhishek P. Effectiveness of brief executive functions-based cognitive remediation in inpatient males with schizophrenia. Indian Journal of Social Psychiatry. 2020;36(1):87-90. [DOI:10.4103/ijsp.ijsp_23_19]
27. Gopi Y, Wilding E, Madan CR. Memory rehabilitation: restorative, specific knowledge acquisition, compensatory, and holistic approaches. Cognitive Processing. 2022;23(4):537-57. [DOI:10.1007/s10339-022-01099-w] [PMID] []
28. Bossert M, Westermann C, Schilling TM, Weisbrod M, Roesch-Ely D, Aschenbrenner S. Computer-assisted cognitive remediation in schizophrenia: efficacy of an individualized vs. generic exercise plan. Frontiers in Psychiatry. 2020;11:555052. [DOI:10.3389/fpsyt.2020.555052] [PMID] []
29. Tan S, Zhu X, Fan H, Tan Y, Yang F, Wang Z, et al. Who will benefit from computerized cognitive remediation therapy? evidence from a multisite randomized controlled study in schizophrenia. Psychological Medicine. 2020;50(10):1633-43. [DOI:10.1017/S0033291719001594] [PMID] []
30. Pourjaberi B, Shirkavand N, Ashoori J. The effectiveness of cognitive rehabilitation training on prospective memory and cognitive flexibility in individuals with depression. International Journal of Education and Cognitive Sciences. 2023;4(3):45-53.
31. Kay S. Positive and negative symdrome scale. (No Title). 1991.
32. Peralta V, Cuesta MJ. Psychometric properties of the positive and negative syndrome scale (PANSS) in schizophrenia. Psychiatry Research. 1994;53(1):31-40. [DOI:10.1016/0165-1781(94)90093-0] [PMID]
33. Periáñez JA, Lubrini G, García-Gutiérrez A, Ríos-Lago M. Construct validity of the stroop color-word test: influence of speed of visual search, verbal fluency, working memory, cognitive flexibility, and conflict monitoring. Archives of Clinical Neuropsychology. 2021;36(1):99-111. [DOI:10.1093/arclin/acaa034] [PMID]
34. Long E, Hill J, Luna B, Verhulst B, Clark D. Disruptive behavior disorders and indicators of disinhibition in adolescents: the BRIEF-SR, anti-saccade task, and D-KEFS color-word interference test. Journal of Adolescence. 2015;44:182-90. [DOI:10.1016/j.adolescence.2015.07.003] [PMID] []
35. Yousefi R, Soleimani M, Ghazanfariyanpoor S. Comparison between switching and creativity among bilingual and monolingual children. Archives of Rehabilitation. 2017;18(1):1-12. [Persian] [DOI:10.21859/jrehab-18011]
36. Niroomand M, Rezaei Dehnavi S, Etemadifar M. The effectiveness of captain log cognitive rehabilitation software on prospective and retrospective memory in people with multiple sclerosis. Research in Cognitive and Behavioral Sciences. 2021;10(2):177-88. [Persian]
37. Yazdanbakhsh K, Azarnia A. The effectiveness of cognitive rehabilitation on improving the cognitive abilities of the elderly. Iranian Journal of Ageing. 2023;18(1):32-45. [Persian] [DOI:10.32598/sija.2022.3258.1]
38. Yamanushi A, Shimada T, Koizumi A, Kobayashi M. Effect of computer-assisted cognitive remediation therapy on cognition among patients with schizophrenia: a pilot randomized controlled trial. Biomedicines. 2024;12(7):1498. [DOI:10.3390/biomedicines12071498] [PMID] []
39. Iwata K, Matsuda Y, Sato S, Furukawa S, Watanabe Y, Hatsuse N, et al. Efficacy of cognitive rehabilitation using computer software with individuals living with schizophrenia: a randomized controlled trial in Japan. Psychiatric Rehabilitation Journal. 2017;40(1):4. [DOI:10.1037/prj0000232] [PMID]
40. Johari S, Zare Neyestanak M, Foroozandeh E. The effectiveness of cognitive rehabilitation in regenerating parietal lobe injuries (episodic memory and shape resorption) in patients with schizophrenia. Journal of Modern Psychological Researches. 2025;17(67):55-66. [Persian]
41. Morimoto T, Matsuda Y, Matsuoka K, Yasuno F, Ikebuchi E, Kameda H, et al. Computer-assisted cognitive remediation therapy increases hippocampal volume in patients with schizophrenia: a randomized controlled trial. BMC Psychiatry. 2018;18:1-8. [DOI:10.1186/s12888-018-1667-1] [PMID] []
42. Fan F, Zou Y, Tan Y, Hong LE, Tan S. Computerized cognitive remediation therapy effects on resting state brain activity and cognition in schizophrenia. Scientific Reports. 2017;7(1):4758. [DOI:10.1038/s41598-017-04829-9] [PMID] []
43. Jung H, Jeong J-G, Cheong Y-S, Nam T-W, Kim J-H, Park C-H, et al. The effectiveness of computer-assisted cognitive rehabilitation and the degree of recovery in patients with traumatic brain injury and stroke. Journal of Clinical Medicine. 2021;10(24):5728. [DOI:10.3390/jcm10245728] [PMID] []
44. Altman RAE, Tan EJ, Rossell SL. Factors impacting access and engagement of cognitive remediation therapy for people with schizophrenia: a systematic review. The Canadian Journal of Psychiatry. 2023;68(3):139-51. [DOI:10.1177/07067437221129073] [PMID] []

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