Background & objectives: Infant feeding is one of the critical periods in the women’s life. Today, considering the multiple dimensions of health, in other words quality of life, is greater measure in assessing the health status. The aim of this study was to investigate quality of life of nursing mothers referring to healthcare centers in Isfahan.

Methods: In this cross-sectional and correlational study, 189 mothers were selected during 2013 by the convenience sampling method in Isfahan. Demographic and World Health Organization WHOQOL- BREF quality of life questionnaire was completed by the each participant. Descriptive and inferential statistics were used to analyze the data in SPSS v.18.

Results: the score of quality of life in breast feeding mothers was higer than other groups, although it was not significant (breast-feeding=85.7±10.6), formula=83.9±12.2 and combination feeding of breast-feeding and formula=82.1±13.1). Mean score of physical dimension of quality of life was significantly different among groups (breastfeeding= 24.7±3.6, formula=23.7±4.1 and combination feeding of breast milk and formula=22.7±4.1), but mean score of social dimension was not different (breast-feeding=10.7±2.3, formula= 10.9±2 and combination feeding of breast milk and formula=10.5±2.2).

Conclusions: According to the results that showed higher quality of life score among the breastfeeding group, we can increase the mother's quality of life by encouraging them for breastfeeding as well as national program and supportive interventions by families and communities such as support and presence of husbands in breast-feeding time.