Background & objectives: Self-control supposed to be one of the basic and fundamental characters of personality that plays important role in overcoming unhealthy desires or impulses and as well doing sociable and normal behaviors. Prior studies have shown the role of religion as preventive and protective for drug addiction in the adolescences. This research aimed to study the role of religious orientation and self-control in prediction of drug addiction potential.

Methods: One hundred and ten female students of Kharazmi University in Iran living in dormitory were selected using convenience sampling method during the first semester (fall semester) in 2014. Research tools included Alport Religious Orientation, short form of Tanjeni self-control and Weed & Butcher drug addiction potential scale. Data were analyzed by Pearson Correlation Coefficient and Multiple Regression Analysis (stepwise).

Results: Result of data analysis showed there was a meaningful relation between intrinsic religious orientation, self-control and risk of drug addiction. Based on multiple regression analysis (stepwise), intrinsic religious orientation and self-control can predict the changes in drug addiction potential up to 19%.

Conclusion: Because of the special and important role of religious beliefs in daily life of people, they play an important role in confronting with deviant behaviors. Moreover, risky and deviant behaviors such as addictions can be prevented through reinforcing self-control skills.