Background & objectives: A group of experts have named the stress as the common disease of the current century. Effect of stress on individuals’ health, depends on their ability to cope. Resiliency is a coping strategy which is useful in facing with stressful situations. The aim of this study was to evaluate the effectiveness of stress management skills on perceived stress and resilience of patients with multiple sclerosis.

Methods: This is an experimental study with pretest-posttest design and the control group. A convenient sample including 45 patients from Kermanshah Multiple sclerosis Association (23 experimental group, 22 control group) was participated in the study. Data analysis was done descriptive statistics and Covariance in SPSS v.21. 

Results: According to the results, mean and standard division in pre-test for perceived stress was 29.78±7.17 and for resiliency was 60.47±20.38; and in the control group mean perceived stress was 32.54± 6.18 and resiliency was 65.50±15.02 respectively which did not changed significantly at posttest. However, in post-test the mean and standard division decreased to 33.36±5.41 and for resiliency it increased to 67.13±13.61 (p<0.001). However the amount of F for perceived stress was 6.61 whereas for resiliency was 168.10. these are significant for both group (p<0.001).

Conclusion: According to the effectiveness of stress management skills on perceived stress and resiliency, it can be considered as an effective solution to reduce perceived stress and increase resiliency and generally improve the mental state of multiple sclerosis patients.