Background & objectives: Cancer makes various changes in quality of life and coping styles and it is supposed that religious attitude of cancer patients has fundamental role in these factors. This study aimed to investigate the structural association between religious attitudes-coping style and quality of life - fatigue in cancer patients.

Methods: This research was a correlational study and research population consists of all cancer patients who had come to Shahid Ghazi Hospital, Tabriz in 2014. From the above-mentioned population, 140 subjects have been selected through available non-random sampling. Patients completed Shahidi and Frajneya’s religious attitude, WHO quality of life, Lazarous and Folkman coping style, and Deriis fatigue questionnaires. Data were analyzed using structural equations model (LISREL) version 8.75 and SPSS v. 19.

Results: The results showed religious attitude and coping style have significant association with quality of life and fatigue (p=0.001). Also equation-structural relationship between religious attitude, coping style, quality of life and fatigue were significant. On the other word, religious attitude can predict quality of life and fatigue with meditating role of coping style. Root Mean Square Error of Approximation (RMSEA=0.05) and Comparative Fit Index (CFI=0.95) were showed that supposed model is suitable in predicting quality of life, fatigue and coping style with dependent role of religious attitude .

Conclusion: Because of the important role of religious attitude in daily life of people, they play important role in confronting disease such as cancer. Enhancing religious attitude in cancer patients will improve the coping style and quality of life and the sense of fatigue would be reduced.