Background & objectives: Invasive diagnostic procedures such as angiography have a lot of stress and anxiety for patients. Anxiety influences the patient’s physiological responses and increases the risks of angiography. The aim of this study was to examine the effect of damask rose extract as a complementary medicine on anxiety of patients undergoing coronary angiography.

Methods: This double blind clinical trial was conducted with participation of 90 patients. With block randomization they assigned into intervention (n=45) and control (n=45). The intervention group received the rose extract in oral form, 15 drops every 8 hours and the control group received the placebo in the similar form and shape, 15 drops every 8 hours. Demographic data sheet, Spielberger questionnaire and hemodynamic index form were used to collect data. Aanxiety questionnaire and hemodynamic index were completed before and after intervention in both groups. Data were analyzed using the Mann-Whitney test, chi-square, Wilcoxon test in SPSS 16 software.

Results: According to the findings of this study, most of the patients were male, married, and under diploma. According to Wilcoxon test, a statistically significant difference was found in anxiety of intervention group before and after the intervention (p<0.001). Also, significant effect was found on systolic blood pressure and mean arterial pressure in the intervention group (p<0.003).

Conclusion: According to the effect of rose extract on anxiety and systolic blood pressure and mean arterial pressure in the group treated with the rose extract, it can be used as complementary medicine alongside other therapy in patients with cardiovascular disease and patients undergoing angiography.